In the unlikely scenario when Pancake leads Grasshopper to crash and lose responsiveness on startup, Safe Mode prevent all 'continuous' features from loading.
Hold Shift Key (any if there is more than one) during the Grasshopper "Loading" screen
You cannot do hot-switch, either.
File Block Monitor
Pancake will still check blocks when this feature is turned on. But the 'monitor' part is entirely disabled.
Debug mode will be enabled.
The menu is
Pancake [Safemode] instead of regular
Pancake if safe mode is enabled.